A novel mouse model provides insights into the neutropenia associated with the ribosomopathy Shwachman-Diamond syndrome.

Artistic representation of the interleukin-7 receptor complex in the plasma membrane of a cell. Editorials 1237 A novel mouse model provides insights into the neutropenia associated with the ribosomopathy Shwachman-Diamond syndrome 1240 JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications Lorraine Springuel, et al. Articles Hematopoiesis 1267 Therapeutic effect of androgen therapy in a mouse model of aplastic anemia produced by short telomeres Christian Bär, et al. 1285 Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes Noemi A. Zambetti, et al. 1294 Panobinostat as part of induction and maintenance for elderly patients with newly diagnosed acute myeloid leukemia: phase Ib/II panobidara study Enrique M. Ocio, et al. 1301 Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia Carmen Vicente, et al.